Allo-HSCT cures adult with congenital dyserythropoietic anemia



David Levy
Photo from David Levy
Physicians have reported what they believe is the first case of an allogeneic hematopoietic stem cell transplant (allo-HSCT) curing an adult with congenital dyserythropoietic anemia (CDA). The patient, David Levy, was previously transfusion-dependent and suffered from iron overload, severe pain, and other adverse effects of... [Read Article]

Model illustrates progression to MDS, AML



Induced pluripotent stem cells
Image by James Thomson
Researchers say they have created a model that shows the step-by-step progression from normal blood cells to acute myeloid leukemia (AML). The team generated induced pluripotent stem cell (iPSC) lines capturing disease stages that included preleukemia, low-risk myelodysplastic syndrome (MDS), high-risk MDS, and AML. The researchers then used... [Read Article]

Study reveals patterns of ED use in SCD patients



doc-and-patient_Credit_St_Jude_Childrens_Research_Hospital_220.jpg
Doctor examines SCD patient
Photo courtesy of St. Jude
Children’s Research Hospital
Population-based surveillance data has revealed patterns of emergency department (ED) visits among Californians with sickle cell disease (SCD). Previous research suggested that between one-half and two-thirds of SCD patients’ ED visits end in a discharge from the ED,... [Read Article]

Genetic profiling can guide HSCT in MDS, team says



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Micrograph showing MDS

Genetic profiling can be used to determine which patients with myelodysplastic syndrome (MDS) are likely to benefit from allogeneic hematopoietic stem cell transplant (HSCT), according to research published in NEJM. Targeted sequencing of 129 genes revealed mutations that, after adjustment for clinical variables, were associated with shorter survival and/or relapse after HSCT. ... [Read Article]