Most blood cancer mutations due to DNA replication errors



DNA helices
Image courtesy of the
National Institute of
General Medical Sciences
A new study supports the idea that most cancer-driving mutations are a result of DNA replication errors, not heredity or lifestyle/environmental factors. For all 32 cancer types studied, researchers found that 66% of driver mutations resulted from DNA replication errors,... [Read Article]

New resource designed to help prevent CINV



Cancer patient
receiving chemotherapy
Photo by Rhoda Baer
The Hematology/Oncology Pharmacy Association (HOPA) has announced the release of a toolkit intended to help prevent chemotherapy-induced nausea and vomiting (CINV) in cancer patients. The Time to Talk CINV™ toolkit was designed to facilitate dialogue between patients and their healthcare teams to ensure no... [Read Article]

Proteins may be therapeutic targets for TKI-resistant CML, ALL



Micrograph showing TKI-
resistant CML in a mouse
Photo courtesy of
Cincinnati Children’s
Hospital Medical Center
Researchers say they have identified 2 signaling proteins that enable resistance to tyrosine kinase inhibitors (TKIs) and could be therapeutic targets for acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML). The team found that by... [Read Article]

MRD predicts outcome of HSCT in ALL, study suggests



HSCT preparation
Photo by Chad McNeeley
Minimal residual disease (MRD) measurements before and after hematopoietic stem cell transplant (HSCT) can help predict outcomes in patients with childhood acute lymphoblastic leukemia (ALL), according to researchers. Their work also suggests several other factors can be used to predict event-free survival (EFS) in this patient population,... [Read Article]