Single-cell analysis reveals TKI-resistant CML stem cells



CML cells
Image by Difu Wu
Researchers say they’ve developed a technique for single-cell analysis that has revealed a population of treatment-resistant stem cells in patients with chronic myeloid leukemia (CML). “It is increasingly recognized that tumors contain a variety of different cell types, including so-called cancer stem cells, that drive the growth... [Read Article]

Proteins may be therapeutic targets for TKI-resistant CML, ALL



Micrograph showing TKI-
resistant CML in a mouse
Photo courtesy of
Cincinnati Children’s
Hospital Medical Center
Researchers say they have identified 2 signaling proteins that enable resistance to tyrosine kinase inhibitors (TKIs) and could be therapeutic targets for acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML). The team found that by... [Read Article]

Imatinib is safe, effective long-term, team says



Imatinib tablet cut
with a pill splitter
Photo by Patrick Pelletier
Long-term follow-up of patients treated with imatinib suggests the drug can remain effective beyond 10 years and does not confer “unacceptable” cumulative toxicity, according to researchers. The group evaluated data on patients who had newly diagnosed, chronic-phase chronic myeloid leukemia (CML) when they... [Read Article]

Styrene exposure linked to myeloid leukemia, HL



Wind turbines in Styria, Austria. Styrene is used in the manufacture of wind turbines.
A new study links styrene—a chemical used in the manufacture of plastics, rubber, and resins—to certain cancers. The research showed that, contrary to previous suggestions, employees who have worked with styrene do not have an increased incidence of esophageal, pancreatic,... [Read Article]

Study quantifies 5-year survival rates for blood cancers



young_adult_pt_receiving_chemo_Credit_Rhoda_Baer_220.jpg
Cancer patient receiving
chemotherapy
Photo by Rhoda Baer

A new study shows that 5-year survival rates for US patients with hematologic malignancies have increased greatly since the 1950s, but there is still room for improvement, particularly for patients with acute myeloid leukemia (AML). Researchers found the absolute difference in improvement for 5-year survival... [Read Article]

Drugs may be effective against hematologic, other cancers



drug_release_in_cancer_cell_credit_PNAS.jpg
Drug release in a cancer cell
Image courtesy of PNAS

A diabetes medication and an antihypertensive drug may prove effective in the treatment of hematologic malignancies and other cancers, according to preclinical research published in Science Advances. Past research has shown that metformin, a drug used to treat type 2 diabetes, has anticancer properties.... [Read Article]