MRD predicts outcome of HSCT in ALL, study suggests

HSCT preparation
Photo by Chad McNeeley
Minimal residual disease (MRD) measurements before and after hematopoietic stem cell transplant (HSCT) can help predict outcomes in patients with childhood acute lymphoblastic leukemia (ALL), according to researchers. Their work also suggests several other factors can be used to predict event-free survival (EFS) in this patient population,... [Read Article]

MSC product granted fast track designation

Mesenchymal stem cells
The US Food and Drug Administration (FDA) has granted fast track designation to a mesenchymal stem cell (MSC) product, MSC-100-IV, as a treatment for children with steroid-refractory acute graft-vs-host disease (aGVHD). MSC-100-IV consists of human MSCs derived from donor bone marrow and expanded in culture. Fast track designation has the potential... [Read Article]

Study advances precision opioid dosing for mucositis

Child with cancer
Photo by Bill Branson
A pilot study to determine the burden of mucositis in pediatric patients undergoing hematopoietic stem cell transplant (HSCT) found that more than 50% of patients required a change in their opioids either for toxicity or lack of efficacy. Investigators also observed that patients’ genotypes were associated with... [Read Article]

Study reveals patterns of ED use in SCD patients

Doctor examines SCD patient
Photo courtesy of St. Jude
Children’s Research Hospital
Population-based surveillance data has revealed patterns of emergency department (ED) visits among Californians with sickle cell disease (SCD). Previous research suggested that between one-half and two-thirds of SCD patients’ ED visits end in a discharge from the ED,... [Read Article]