Synthetic heparin poised for clinical trials, team says

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Lab mouse
Researchers say they have synthesized low molecular weight heparin (LMWH) that may someday replace animal-sourced heparin. The team created heparin dodecasaccharides (12-mers) using a manufacturing method that yielded gram quantities—roughly 1000-fold more than previous approaches used to synthesize LMWHs. One of these dodecasaccharides, called 12-mer-1, demonstrated safety and efficacy in animals... [Read Article]
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Height is independent predictor of VTE

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Thrombus
Image by Kevin MacKenzie
Taller individuals have an increased risk of venous thromboembolism (VTE), according to research published in Circulation: Cardiovascular Genetics. In a study of more than 2 million Swedish siblings, researchers found that height was an independent predictor of VTE, with the lowest VTE risk observed in the shortest participants.... [Read Article]
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Study: Two antithrombotic drugs better than 3

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Dabigatran
Photo courtesy of
Boehringer Ingelheim
A new study suggests a combination of 2 antithrombotic drugs is as effective as, but safer than, a 3-drug combination for patients with atrial fibrillation who have undergone percutaneous coronary intervention (PCI). The combinations were similarly effective in preventing thromboembolic events, unplanned revascularization, or death. But... [Read Article]
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Therapy shows promise for PUPs with severe hemophilia A

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Simoctocog alfa
Photo from Octapharma
A fourth-generation recombinant factor VIII (FVIII) therapy has demonstrated “convincing” efficacy and tolerability as well as low immunogenicity in previously untreated patients (PUPs) with severe hemophilia A, according to researchers. The therapy, simoctocog alfa, is a B-domain-deleted recombinant FVIII product derived from a human cell line. In the... [Read Article]
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Watching von Willebrand factor in action

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Thrombus
Image by Andre E.X. Brown
Researchers have gained “important mechanistic insights” into how von Willebrand factor (VWF) controls bleeding, according to an article published in Nature Communications. Fluorescence imaging and microfluidic tools allowed the researchers to capture images of individual VWF molecules on camera while manipulating the molecules with life-like mechanical forces... [Read Article]
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