Group creates ‘authentic’ HSCs from endothelial cells

Hematopoietic stem cells
in the bone marrow
Researchers say they have found a way to convert adult mouse endothelial cells into “authentic” hematopoietic stem cells (HSCs). The team says these HSCs have a transcriptome and long-term self-renewal capacity that are similar to those of adult HSCs that are produced naturally. In addition, the lab-generated... [Read Article]

Intensive chemo upfront means DHL patients can skip HSCT

Cancer patient receiving chemotherapy
Photo by Rhoda Baer
A new study suggests that patients with double-hit lymphoma (DHL) in first remission only benefit from an autologous hematopoietic stem cell transplant (auto-HSCT) if they received standard frontline chemotherapy. Researchers looked at long-term outcomes for DHL patients who achieved remission and, overall, found that auto-HSCT... [Read Article]

CMV matching improves survival in HSCT recipients

Micrograph showing
CMV infection
Matching the cytomegalovirus (CMV) status of the donor and recipient of a hematopoietic stem cell transplant (HSCT) can significantly improve the recipient’s survival, according to a study published in Bone Marrow Transplantation. In fact, researchers said they found evidence to suggest that CMV matching may abrogate the effect of... [Read Article]

Study shows similar outcomes with RIC and MAC in MDS

HSCT preparation
Photo by Chad McNeeley
Results of a phase 3 trial revealed similar outcomes in patients who underwent allogeneic hematopoietic stem cell transplant (allo-HSCT) to treat myelodysplastic syndromes (MDS), regardless of the conditioning regimen they received. Rates of engraftment, graft-vs-host disease (GVHD), relapse, and survival were similar between patients who received reduced-intensity... [Read Article]

Method could prevent GVHD while preserving GVL effect

Micrograph showing GVHD
Image from PLOS ONE
Researchers believe they have found a way to prevent graft-versus-host disease (GVHD) after hematopoietic stem cell transplant (HSCT) while preserving a strong graft-versus-leukemia (GVL) effect. In experiments with mice, the team found that temporary in vivo depletion of CD4+ T cells soon after HSCT prevented GVHD... [Read Article]