Researchers say they’ve discovered another viable approach for cancer vaccines: using the macrophage pathway to program killer T cells against cancers. The team had previously shown that nearly all cancer cells use the molecule CD47 to escape from being eliminated by macrophages. The group also found that anti-CD47 antibodies, which can block CD47’s signal and enable macrophages to engulf cancer cells, inhibited the growth of various hematologic cancers and solid tumors.  [Read Article]

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