Hematology Times
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TransplantationTeam uses iPSCs, teratomas to generate HSCs
Colony of iPSCs
Credit: Salk Institute Researchers say they’ve devised a method for creating functional hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs). The team found they could generate engraftable HSCs by injecting either mouse- or human-derived iPSCs into mice and allowing those cells to form teratomas. When transplanted into other mice, these teratoma-derived HSCs engrafted and demonstrated self-renewal potential but did not induce leukemia or other malignancies. [Read Article] Group sheds new light on cells that produce IL-17
T cells
Credit: NIAID Researchers have found evidence to suggest that cells producing interleukin 17 (IL-17) are not all the same. And it seems the rules for producing IL-17 differ according to cell type. As previous research has indicated that increasing numbers of IL-17-producing cells herald the development of acute graft-vs-host disease, these new findings could aid the study of hematopoietic stem cell transplant. Gary Koretzky, MD, PhD, of the University of Pennsylvania, and his colleagues described the findings in Nature Immunology. [Read Article] Method allows for mass production of NK cells
NK cell in action
Credit: Bjorn Onfelt/Dan Davis Scientists have reported a way to produce natural killer (NK) cells in a quantity that could one day make them viable for treating patients. While producing natural killer (NK) cells from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) has become routine, it’s been on a limited scale. But this study, published in STEM CELLS Translational Medicine, shows how to increase the number of resulting cells while also reducing the amount of work and time involved in producing them. [Read Article] Discovery could help improve hematopoietic recovery
HSCs for transplant
Credit: Chad McNeeley A new study has shown that chemotherapy induces an insidious type of nerve damage in bone marrow that can cause delays in recovery after hematopoietic stem cell transplant (HSCT). The discovery, made in mice and published in Nature Medicine, suggests that combining chemotherapy with nerve-protecting agents may prevent long-term bone marrow injury that causes anemia and may improve the success of transplants. In an earlier study, Paul Frenette . . . [Read Article] Fractals could help predict SCT outcomes
Romanesco broccoli, a natural
approximation of a fractal Credit: Jon Sullivan A new study suggests that self-similar, repeating patterns in nature—known as fractals—can help scientists better understand how the immune system is organized. In fact, the research indicates that fractals could be used to help improve stem cell transplant (SCT) outcomes by predicting the probability of transplant complications. Reporting in Biology of Blood and Marrow Transplantation, a group of researchers described how they found a fractal pattern in the T-cell repertoire . . . [Read Article] |
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