Investigators question utility of SFLCA

Won Sok Lee (left)
and Gurmukh Singh
Photo by Phil Jones,
Augusta University
Researchers are questioning the clinical usefulness of the serum free light chain assay (SFLCA) for patients with monoclonal gammopathies. The investigators found evidence suggesting that, about 25% of the time, SFLCA provides a negative κ/λ ratio in patients with lambda chain monoclonal gammopathies who have free homogenous lambda light chains detectable in their urine. [Read Article]

Vaccine protects mice from malaria

Lab mice
Photo by Aaron Logan
An RNA replicon-based vaccine can fight malaria infection in mice, according to research published in Nature Communications. The vaccine targets a protein, Plasmodium macrophage migration inhibitory factor (PMIF), which is produced by malaria parasites and suppresses memory T cells. The vaccine provided improved control of existing malaria infection as well as protection from reinfection in mice. [Read Article]

PET-guided treatment didn’t improve outcomes

PET scan
Image from Jens Langner
In the PETAL trial, treatment intensification based on results of an interim positron emission tomography (PET) scan did not improve survival outcomes for patients with aggressive lymphomas. PET-positive patients did not benefit by switching from R-CHOP to a more intensive chemotherapy regimen. PET-negative patients did not benefit from 2 additional cycles of rituximab after R-CHOP. [Read Article]