Plasma transfusion during air transport can reduce mortality

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Bags of plasma
Photo by Cristina Granados
Receiving a plasma transfusion during emergency air transport can improve survival for trauma patients, according to a study published in NEJM. Trauma patients with severe bleeding had a significant decrease in 30-day mortality when they received a plasma transfusion while being airlifted to a hospital. Transfusion-related reactions and... [Read Article]
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Turbulence aids platelet production

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Megakaryocytes in the bone marrow
Turbulence promotes large-scale production of functional platelets from human induced pluripotent stem cells (hiPSCs), according to research published in Cell. Exposure to turbulent energy in a bioreactor stimulated hiPSC-derived megakaryocytes to produce 100 billion platelets. Transfusion of these platelets in 2 animal models promoted blood clotting and prevented bleeding just... [Read Article]
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Study links gut bacteria and TRALI

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Blood for transfusion
Photo by Elise Amendola
A new study has revealed a previously unknown link between gastrointestinal flora and transfusion-related acute lung injury (TRALI). “We observed that the composition of the gastrointestinal flora drives the pathogenic immune response in the lungs during TRALI,” said Rick Kapur, PhD, of Lund University in Lund, Sweden.... [Read Article]
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FDA grants EUA for freeze-dried plasma product

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US soldiers in Afghanistan
Photo by Kyle Davis
The US Food and Drug Administration (FDA) has granted emergency use authorization (EUA) for a freeze-dried plasma product to be used by the military. The product is Pathogen-Reduced Leukocyte-Depleted Freeze-Dried Plasma manufactured by the Centre de Transfusion Sanguine des Armées, referred to in the EUA as “French... [Read Article]
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Better matching for blood transfusions

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Blood for transfusion
Photo by Elise Amendola
Researchers have developed software that could enable more precise matching for blood transfusions, according to a paper published in The Lancet Haematology. The software, bloodTyper, can automatically type red blood cell (RBC) and platelet antigens from whole-genome sequencing (WGS) data. In repeated tests, bloodTyper produced results that... [Read Article]
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FDA approves new use for Zika test

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Blood for transfusion
Photo from UAB Hospital
The US Food and Drug Administration (FDA) has approved an additional use for the cobas Zika test. The approval allows for the streamlined screening of multiple individual blood or plasma donations that have been pooled together. The cobas Zika test is a qualitative in vitro nucleic acid screening... [Read Article]
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Producing compatible RBCs for transfusion

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Red blood cells
Researchers say they have found a way to generate customized red blood cells (RBCs) that might one day be used to avoid transfusion incompatibilities. The team used genome editing to modify an erythroblast cell line, making it deficient in antigens responsible for common transfusion incompatibilities. The cells in this line could... [Read Article]
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Health Canada approves blood system for platelets

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Platelets for transfusion
Photo from Flickr
Health Canada has approved commercialization of the INTERCEPT Blood System for platelets, which is used for the ex vivo treatment and storage of platelet components. The INTERCEPT Blood System for platelets can inactivate a range of pathogens—including viruses, bacteria, and protozoan parasites—to reduce the risk of transfusion-transmitted infections.... [Read Article]
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