Optimizing use of TKIs in CML

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Hagop Kantarjian, MD
Long-term efficacy and toxicity should inform decisions about tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML), according to the keynote presenter at Leukemia and Lymphoma: Europe and the USA, Linking Knowledge and Practice. Studies have indicated that long-term survival rates are similar whether CML patients receive frontline treatment with imatinib... [Read Article]
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AMP publishes report on DNA variants in CMNs

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Polycythemia vera
Image courtesy of AFIP
A new report addresses the clinical relevance of DNA variants in chronic myeloid neoplasms (CMNs). The report is intended to aid clinical laboratory professionals with the management of most CMNs and the development of high-throughput pan-myeloid sequencing testing panels. The authors list 34 genes they consider “critical” for sequencing... [Read Article]
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Familial risk of myeloid malignancies

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Three generations of
women in a family
A large study has revealed “the strongest evidence yet” supporting genetic susceptibility to myeloid malignancies, according to a researcher. The study showed that first-degree relatives of patients with myeloid malignancies had double the risk of developing a myeloid malignancy themselves, when compared to the general population. The researchers... [Read Article]
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CHMP backs approval of dasatinib for kids

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CML cells
Image by Difu Wu
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended changes to the marketing authorization for dasatinib (Sprycel). The CHMP is recommending approval for dasatinib as a treatment for pediatric patients with newly diagnosed, Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase... [Read Article]
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Agent exhibits activity in leukemias, MDS

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AML cells
The experimental agent prexigebersen (formerly BP1001) was considered well-tolerated and demonstrated early evidence of activity against relapsed/refractory hematologic disorders in a phase 1/1b trial. The drug reduced blasts in the bone marrow and peripheral blood for patients with acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and myelodysplastic syndrome (MDS). When given... [Read Article]
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FDA approves nilotinib for kids with CML

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Nilotinib (Tasigna)
Photo from Novartis
The US Food and Drug Administration (FDA) has expanded the approved indication for nilotinib (Tasigna®) to include the treatment of children. The drug is now approved to treat patients age 1 and older who have newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in the chronic phase. Nilotinib... [Read Article]
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Drug could improve treatment of CML, team says

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Lab mouse
A microRNA-targeting drug could improve the effectiveness of tyrosine kinase inhibitors (TKIs) against chronic myelogenous leukemia (CML), according to preclinical research published in Nature Medicine. The drug, miristen, targets miR-126, a microRNA expressed in leukemia stem cells (LSCs). Researchers found that miristen “enhanced the anti-leukemic effects of TKI treatment” in mouse... [Read Article]
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CHMP backs bosutinib for newly diagnosed CML

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CML cells
Image by Difu Wu
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended expanding the approved use of bosutinib (BOSULIF) to include treatment of patients with newly diagnosed, chronic phase, Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Bosutinib is currently approved in Europe to treat patients with... [Read Article]
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Expanded UCB product can stand alone

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Mitchell Horwitz, MD
The expanded umbilical cord blood (UCB) product NiCord can be used as a stand-alone graft, according to research presented at the 2018 BMT Tandem Meetings. Researchers found that a single NiCord unit provided “robust” engraftment in a phase 1/2 study of patients with high-risk hematologic malignancies. NiCord recipients had quicker... [Read Article]
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