Lymphodepletion improves efficacy of CAR T cells in HL

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Crowd exiting a session at the 2018 ASH Annual Meeting
© ASH/Rodney White 2018
A phase 1 study suggests lymphodepletion can improve the efficacy of CD30-directed chimeric antigen receptor (CAR) T-cell therapy in patients with Hodgkin lymphoma (HL). Researchers observed improved responses in HL patients treated with fludarabine and cyclophosphamide prior to CD30.CAR... [Read Article]
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Fludarabine deemed important for CD30.CAR T-cell therapy

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Attendees at ASH 2018
Photo courtesy of ASH
Fludarabine is “very important” for lymphodepletion prior to CD30-directed chimeric antigen receptor (CAR) T-cell therapy, according to a presentation at the 2018 ASH Annual Meeting. A phase 1/2 study showed that bendamustine alone was not sufficient as lymphodepletion. However, adding fludarabine to bendamustine could enhance responses... [Read Article]
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System may better predict thrombosis in lymphoma

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Audience at Leukemia and Lymphoma: Europe and the USA, Linking Knowledge and Practice
An updated scoring system can more accurately identify lymphoma patients who may require thromboprophylaxis, according to researchers. The revised scoring system, ThroLy, proved more effective than other systems for predicting thromboembolic events in lymphoma patients. Researchers found the updated ThroLy had... [Read Article]
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Drug approved as part of frontline therapy for HL

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Brentuximab vedotin
Photo from Business Wire
The Japanese Ministry of Health, Labour and Welfare has approved brentuximab vedotin (Adcetris) in combination with doxorubicin, vinblastine, and dacarbazine as a frontline treatment option for CD30-positive Hodgkin lymphoma (HL). The approval was based on the phase 3 ECHELON-1 trial. Result from ECHELON-1 were presented at the 2017 ASH... [Read Article]
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Guidelines for proton therapy in mediastinal lymphomas

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Treatment room at the
Roberts Proton Therapy
Center at the University
of Pennsylvania.
Photo from Penn Medicine
Proton therapy can help mitigate toxicity in adults with mediastinal lymphomas, but the treatment should only be used in patients expected to derive the most benefit, according to new guidelines from the International Lymphoma Radiation Oncology Group. The... [Read Article]
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Role of SES in childhood cancer survival disparities

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Child with cancer
Photo by Bill Branson
Socioeconomic status (SES) may explain some racial/ethnic disparities in childhood cancer survival, according to new research. The study showed that whites had a significant survival advantage over blacks and Hispanics for several childhood cancers. SES significantly mediated the association between race/ethnicity and survival for acute lymphoblastic leukemia (ALL),... [Read Article]
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Frequent BCCs linked to blood cancers

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Woman sunbathing
New research suggests people who develop frequent cases of basal cell carcinoma (BCC) have an increased risk of leukemias, lymphomas, and other cancers. “We discovered that people who develop 6 or more basal cell carcinomas during a 10-year period are about 3 times more likely than the general population to develop other, unrelated... [Read Article]
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Adult CCSs report financial hardships

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I-Chan Huang, PhD
Photo from St. Jude
Children’s Research
Hospital/Peter Barta
Health-related financial hardship is common among adult survivors of childhood cancer, according to a study published in the Journal of the National Cancer Institute. Researchers analyzed more than 2800 long-term childhood cancer survivors (CCSs) and found that 65% had financial challenges related to their... [Read Article]
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FDA approves biosimilar filgrastim

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Vials of drug
Photo by Bill Branson
The US Food and Drug Administration (FDA) has approved the leukocyte growth factor Nivestym™ (filgrastim-aafi), a biosimilar to Neupogen (filgrastim). Nivestym is approved to treat patients with nonmyeloid malignancies who are receiving myelosuppressive chemotherapy or undergoing bone marrow transplant, acute myeloid leukemia patients receiving induction or consolidation chemotherapy,... [Read Article]
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