Groups launch open portal for cancer models

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Researcher in the lab
Photo by Darren Baker
The European Bioinformatics Institute (EMBL-EBI) and The Jackson Laboratory (JAX) have developed an open cancer research portal for patient-derived xenograft (PDX) models. The portal, known as PDX Finder, catalogues PDX models from numerous global repositories. At present, PDX Finder contains more than 1900 models for... [Read Article]
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Generic antiemetic now available in US

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Fresenius Kabi’s Palonosetron
Hydrochloride Injection
Photo from Business Wire
Palonosetron Hydrochloride Injection, a generic alternative to Aloxi®, is now available in the US. Fresenius Kabi’s Palonosetron Hydrochloride Injection is a 5-HT3 serotonin receptor that is approved for the prevention of nausea and vomiting in certain adults. Palonosetron Hydrochloride Injection is available in a single-dose... [Read Article]
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Why iron can worsen malaria infection

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Malaria-infected cell bursting
Image by Peter H. Seeberger
Researchers believe they may have discovered why iron can sometimes worsen malaria infection. By studying mice and samples from malaria patients, the researchers found that extra iron interferes with ferroportin, a protein that prevents a toxic buildup of iron in red blood cells and helps protect these... [Read Article]
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At-home measurement of WBCs

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Red and white blood cells
A portable device could be used to monitor patients’ white blood cell (WBC) levels at home, without the need for blood samples, according to researchers. The team created a prototype that records video of blood cells flowing through capillaries just below the skin surface at the base of the... [Read Article]
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How RBCs maintain their shape

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From left to right:
Study authors Velia
Fowler, Alyson Smith,
and Roberta Nowak
Photo by Don Boomer
New research indicates that non-muscle myosin II-A (NMIIA) plays a key role in maintaining red blood cell (RBC) shape and deformability. Researchers found evidence to suggest that NMIIA forms filaments in RBCs, and specialized regions at both... [Read Article]
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Clinical trial registries don’t match up

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Preparing drug for a trial
Photo by Esther Dyson
A new study has revealed discrepancies in completion status for trials listed on ClinicalTrials.gov and the EU Clinical Trials Register (EUCTR). Researchers evaluated nearly 10,500 trials listed on both registries and found that roughly 16% of them were marked as “completed” on one registry and... [Read Article]
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