Markers associated with efficacy of malaria vaccine

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Child receiving RTS,S/AS01
Photo by Caitlin Kleiboer
New research has revealed markers associated with efficacy of the RTS,S/AS01E malaria vaccine (Mosquirix™). The study suggests malaria protection depends on the amount and subclass of antibodies generated upon vaccination and on previous exposure levels to the malaria parasite. Researchers believe these findings, published in BMC Medicine,... [Read Article]
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Palliative care guidelines relevant for hematologists, doc says

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Husband holding hands
with wife in hospital
Photo from Pexels
The latest edition of the national palliative care guidelines provides new clinical strategies relevant to hematology practice in the United States, according to a physician-researcher specializing in hematology. The guidelines represent a “blueprint for what it looks like to provide high-quality, comprehensive palliative care... [Read Article]
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Better PFS may not mean better HRQOL

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Preparing drug for a trial
Photo by Esther Dyson
Cancer treatments that prolong progression-free survival (PFS) may not improve health-related quality of life (HRQOL), researchers reported in JAMA Internal Medicine. The researchers failed to find a significant association between PFS and HRQOL in an analysis of cancer clinical trials. “There are only two reasons... [Read Article]
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New guidelines for idiopathic multicentric Castleman disease

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David C. Fajgenbaum, MD
Photo from Penn Medicine
The anti-IL-6 antibody siltuximab is central to first-line treatment of idiopathic multicentric Castleman disease (iMCD), according to new guidelines on iMCD published in Blood. The guidelines also say that early intervention with combination chemotherapy may prevent a fatal outcome in patients with severe iMCD. To create... [Read Article]
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ASCO addresses financial barriers to cancer clinical trials

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Preparing drug for a trial
Photo by Esther Dyson
The American Society of Clinical Oncology (ASCO) has issued a policy statement addressing financial barriers to patient participation in cancer clinical trials. ASCO’s policy statement outlines a series of recommendations designed to address multiple financial barriers that impede access to clinical trials, including patient costs that... [Read Article]
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Physician burnout linked to patient safety

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Doctor with tablet
Photo by George Hodan
Physician burnout may jeopardize patient care, according to research published in JAMA Internal Medicine. A review and meta-analysis suggested that physician burnout was associated with a higher risk of patient safety incidents, reduced patient satisfaction, and low professionalism. Burnout was defined as “a response to prolonged exposure... [Read Article]
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New guidelines on antimicrobial prophylaxis

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Cancer patient
receiving treatment
Photo by Rhoda Baer
Experts have published updated guidelines on antimicrobial prophylaxis for adults with cancer-related immunosuppression. The guidelines include antibacterial, antifungal, and antiviral prophylaxis recommendations, along with additional precautions, such as hand hygiene, that may reduce infection risk. The guidelines were developed by the American Society of Clinical Oncology (ASCO)... [Read Article]
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Humans may have more HSCs than we thought

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HSCs in the bone marrow
Humans may have ten times more hematopoietic stem cells (HSCs) than previously thought, according to research published in Nature. Researchers developed a new approach for studying HSCs and found evidence suggesting that HSC numbers increase rapidly through childhood, reach a plateau by adolescence, and remain relatively constant throughout adulthood. “We... [Read Article]
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